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Ansonville, one of the oldest communities in Anson County, traces its roots to the mid-18th century when settlers began moving into the Pee Dee River Valley. The area was originally inhabited by Native American tribes, particularly the Catawba and Pee Dee peoples, whose presence shaped the region's cultural and geographical foundation. With the formation of Anson County in 1750, settlers—mainly of English, Scotch-Irish, and German descent—established farms along the fertile lands near the river. These pioneers laid the groundwork for what would become the town of Ansonville, officially chartered in the early 19th century.

Agriculture was the cornerstone of Ansonville's early economy. The fertile soil supported crops such as cotton, corn, and tobacco, while small gristmills and sawmills dotted the landscape. The growth of the cotton trade in the 1800s brought wealth and development to the area, supported by the construction of rail lines that connected Anson County to Charlotte and other regional markets. Local merchants and craftsmen contributed to the town's prosperity, making Ansonville a modest yet vibrant rural hub.

Transportation improvements in the late 19th and early 20th centuries further transformed the town. The expansion of railroads and later, paved highways such as NC-52, enhanced commerce and accessibility. These routes linked Ansonville to neighboring towns like Wadesboro and Albemarle, encouraging both trade and cultural exchange. Although the textile industry grew rapidly in nearby counties, Ansonville retained its agricultural roots, maintaining the traditional character that still defines it today.

Throughout the 20th century, Ansonville's community life revolved around its churches, schools, and local gatherings. Small-town institutions played vital roles in maintaining a sense of unity among residents. Despite fluctuations in population and industry, the town has preserved its historic charm and deep connection to the land. Local pride in heritage remains evident through preservation efforts and community-led events celebrating Anson County's farming and frontier past.

Today, Ansonville is a peaceful rural town where historic legacy meets Southern hospitality. Its proximity to the Pee Dee River and scenic countryside appeals to those seeking tranquility and natural beauty. The community continues to embrace progress while honoring its heritage, offering a welcoming atmosphere for families and individuals who value small-town life.