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Point South, South Carolina, sits strategically at the crossroads of Jasper and Beaufort Counties, where Interstate 95 meets U.S. Highway 17. Though small in population and size, Point South's location has made it one of the Lowcountry's most important transportation and hospitality hubs for centuries. The region surrounding Point South was originally home to Native American groups who relied on the nearby Broad and Coosawhatchie Rivers for fishing, trade, and transport. During the colonial period, the Lowcountry became a key area for rice and indigo cultivation, and early settlers used the land around present-day Point South as a throughway between the inland plantations and coastal ports like Beaufort and Charleston.

By the 19th century, the area near Point South had developed a modest agricultural presence, with small farms and timber industries serving local markets. Its proximity to the Savannah River corridor and the Charleston-Savannah trade route brought steady movement of goods and travelers through the region. After the Civil War, like much of the Lowcountry, this area experienced economic decline as plantations were abandoned and the agricultural economy restructured. African American communities formed in the surrounding countryside, sustaining Gullah-Geechee traditions and establishing churches, schools, and farms that would define the postwar era in the region.

The area's importance grew again in the mid-20th century with the construction of major roadways. The completion of U.S. Highway 17 and later Interstate 95 transformed Point South into a vital junction for travelers moving along the Eastern Seaboard. The interchange became known as a gateway to South Carolina's coastal destinations, offering rest stops, hotels, and services for those heading toward Hilton Head, Beaufort, or Savannah. Businesses sprang up around the intersection, serving a mix of tourists, truckers, and regional commuters. This infrastructure gave Point South a lasting role as a hub for commerce and transportation in the South Carolina Lowcountry.

Despite being a largely commercial stop, Point South is surrounded by some of the most scenic and historically rich landscapes in the state. The nearby ACE Basin—an ecological preserve named for the Ashepoo, Combahee, and Edisto Rivers—stands as one of the largest undeveloped estuaries along the Atlantic Coast. It provides a haven for wildlife and offers visitors a glimpse into the natural beauty that once dominated much of coastal South Carolina. Communities surrounding Point South, including Yemassee and Sheldon, also preserve historic churches, plantations, and cemeteries dating back to the 1700s.

Today, Point South is known primarily as a welcoming rest and service center for travelers exploring the Lowcountry. The area has embraced its identity as both a commercial hub and a gateway to South Carolina's coastal charm. Its proximity to Beaufort, Hilton Head Island, and Savannah makes it an ideal launching point for visitors seeking history, culture, and natural beauty. Residents and local business owners take pride in maintaining the region's hospitality and character while supporting conservation efforts that protect the area's marshes, forests, and waterways. In essence, Point South remains true to its name—a vital point of connection linking the South's past, present, and future.