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Sampson, located in Sampson County, North Carolina, has a history shaped by agriculture, transportation, and rural community development. Prior to European settlement, the area was inhabited by Indigenous peoples who thrived along the Cape Fear River and its tributaries. These early residents relied on hunting, fishing, and cultivation for sustenance. European settlers arrived in the 18th century, establishing farms and small trading posts. Sampson County was formed in 1784, and communities such as Sampson gradually emerged as local centers of trade and agriculture. The town's name honors the county itself, reflecting its role as a hub within the broader rural region.

Agriculture was the cornerstone of Sampson's economy throughout the 19th century. Farmers cultivated tobacco, cotton, corn, and a variety of livestock, supplying both local markets and regional trade centers. Small mills, general stores, and trading posts supported the community, making Sampson a key location for surrounding rural areas. The town's economy benefited from its fertile soil and proximity to larger towns like Clinton and Newton Grove, where agricultural products could be sold. Over time, Sampson developed a reputation as a hardworking, agriculturally focused community with strong local ties.

Infrastructure development played a significant role in Sampson's evolution. Early roads connected the town to surrounding communities, facilitating trade and travel. The introduction of rail lines in the late 19th century further expanded economic opportunities, linking Sampson to markets throughout eastern North Carolina. In the 20th century, highway improvements, including NC-24 and NC-50, increased accessibility, encouraging population growth and modest suburban expansion. These transportation links allowed Sampson residents to commute to larger towns for work while maintaining a rural lifestyle.

Community life in Sampson has historically centered on family, faith, and education. Churches provided spiritual guidance and venues for social gatherings, while schools became focal points for education and community engagement. Seasonal events, fairs, and markets reinforced social cohesion and celebrated local culture. The town's residents have preserved a strong sense of identity, valuing traditions rooted in agriculture and community cooperation, while embracing gradual modernization over time.

Today, Sampson continues to balance its agricultural heritage with modern living. Residential areas provide a mix of historic homes and newer developments, while farms in the surrounding countryside remain productive. Local schools, parks, and community amenities support a high quality of life, and the town's strategic location allows residents easy access to larger urban centers such as Fayetteville and Dunn. Sampson remains a welcoming community that honors its history while adapting to contemporary needs, offering a strong sense of place and identity for its residents.